How can ‘Now and So’ be Now and So?

So what do we call GPR18 now?

The further characterization of the orphan GPCR GPR18 conducted by McHugh et al. in this issue of the British Journal of Pharmacology has generated a pharmacological profile that raises some interesting questions about the nomenclature of this receptor and may also prompt some questions about the pharmacological definition of the classical cannabinoid receptors, CB(1) and CB(2) . LINKED ARTICL...

We Had So Much Fun. Now What?

The declining enrollment is a dilemma that many information systems programs are facing. In this study, we design a “Mobile Star” project to promote the information systems major to high school students in Texas. Each “Mobile Star” project consists of a mobile app development workshop and the student’s app showcase. We expect to explore whether the student’s perceived completion, perceived achi...

Diastolic heart failure: what, so what and now what?

The Elephant in the Room Until two decades ago, the notion that heart failure (HF) could occur in the presence of normal ejection fraction (EF) was met with great skepticism. While most physicians could recall encounters with hypertensive elderly ladies in acute pulmonary oedema despite a normal EF, it was not until large epidemiologic studies provided evidence for the existence of this syndrom...

["So, are we going to treat cancer now?"].

How Can Governments Borrow so Much?

We analyze the determinants of government debt under the twin assumptions that governments have limited horizons and default only when government income falls short of debt service requirements. We derive a government’s maximum sustainable debt ratio, that is, the debt ratio chosen by a myopic government whose horizon does not extend beyond its current term in office. Maximum sustainable debt v...